Design of novel beta-blockers for the retardation of breast cancer metàstasis

Identifier:  TFG:2575

Handle: https://hdl.handle.net/20.500.11797/TFG2575

Authors:  Martí Zaragoza, Àlex

Abstract:
The synthesis of new analogues of the beta-blocker Propranolol has been explored. According to recent studies, 2-biphenyls rather than naphthalene rings provide compounds with promising β2 -ADR inhibitor properties. The project aimed to produce new derivatives with a methyl group at different positions on the substituted phenyl ring of the biphenyl moiety. Methods for preparing the appropriate iodo-cresols were explored. Two such compounds, derived from the p-cresol and m-cresol, were then converted to the final compounds by Suzuki coupling, reaction with an epoxy tosylate and ring opening with isopropylamine. However, the final products could not be fully purified and only small amounts with a few impurities were obtained. All compounds were characterized by 1H and 13C NMR.