Identifier: TFG:878
Authors: Malapeira González, Júlia
Abstract:
Introduction: Hesperidin, a flavanone present in oranges, could improve blood pressure (BP) and endothelial function (EF) in individuals with high cardiovascular risk. The aim of the study is to evaluate the effect of an orange juice enriched with hesperidin on reducing BP and EF during 4 weeks of consumption. Methods: 30 participants (21 men and 9 women) with prehypertension or grade 1 Hypertension (HTA) have received 500 mL of juice (x, y or z) with different content of hesperidin in a randomized, parallel, double-blind, placebo-control study. During one month follow-up were made some visits (V1, V2, V3) to evaluate BP in every visit and FE, measured as ischemic reactive hyperemia (IRH), at V1 and V3. Statistical analysis has performed with SPSS version 23 considering p value <0.05. Results: Juice-x reduces systolic-BP (mean ± standard deviation) in 7.25 ± 8,18 mm Hg and diastolic-BP in 7.00 ± 4,65 mm Hg between V1 and V3 in a significantly way (p <0.05). It hasn’t detected any significant change in the IRH between V1 and V3 for any juice but significant differences were detected in IRH between juice-y and juice-z (p = 0.017). Body weight remained stable during 4 weeks study. It has been detected significant decrease in physical activity between V1 and V2 for the juice-x (p=0.003) for the juice-y (p=0.019) and for juice-z (p=0.001). Juice-z also showed significant decrease in physical activity between V2 and V3 (p=0.013) and between V1 and V3 (p=0.047). Conclusions: Regular intake of juice-x could help reduce levels of systolic-BP and diastolic-BP in individuals with prehypertension or grade 1 HTA. The study remains active and must be completed to relate the BP differences with the hesperidin content in each juice. Key words: hesperidin, orange juice, blood pressure, endothelial function, hypertension.
Repositori URV