Identifier: TFG:8855
Authors: Hernández Armas, Iván
Abstract:
Morus alba L. (white mulberry) is a multifunctional plant traditionally used in Asian medicine, increasingly recognized for its rich phytochemical profile and potential therapeutic applications. Its leaves, fruits, and roots are rich in bioactive compounds such as flavonoids, phenolic acids, alkaloids and polysaccharides, which exhibit antioxidant, anti-inflammatory, antidiabetic, and hypolipidemic activities. Chronic kidney disease (CKD), a growing global health concern, is closely associated with metabolic risk factors including diabetes, hypertension, obesity, and dyslipidemia. Recent studies suggest that Morus alba may contribute to renal protection by modulating these risk factors and acting directly on renal structures through anti-inflammatory, antioxidant, and gut microbiota-mediated mechanisms. This review aims to summarize the current scientific evidence regarding the potential nephroprotective effects of Morus alba, integrating data from in vitro, animal, and human studies. The findings highlight the role of Morus alba in improving metabolic parameters, attenuating renal inflammation and oxidative stress, and modulating the gut–kidney axis. Although promising, further clinical research is required to clarify its mechanisms, safety, and long-term effectiveness as a complementary dietary strategy for the prevention and management of CKD.
Repositori URV