Metal-Free -Fluoroamination of Allyl Carbamates: Towards the Synthesis of Fluorinated Sphingolipid Analogs

Entity: Universitat Rovira i Virgili (URV)

Confidenciality: No

Education area(s): Síntesi, Catàlisi i Disseny Molecular

Title in different languages: Metal-Free -Fluoroamination of Allyl Carbamates: Towards the Synthesis of Fluorinated Sphingolipid Analogs

Abstract: The study of sphingolipid analogs as inhibitors for sphingosine kinase has emerged as a therapeutic target against cancer. In this context, I have described the synthesis of different -Fluoroamine scaffolds with the aim of synthesizing 3-fluorinated sphingolipid analogs starting from dienyl carbamates. The approach envisaged comprises an intramolecular aziridination of dienyl carbamates using hypervalent iodine species followed by ring-opening of the aziridine intermediate with a Fluorine source.

Subject: química

Academic year: 2021-2022

Language: en

Work's public defense date: 2022-07-21

Subject areas: Chemistry

Student: Plaza Luna, Jorge

Department: Química Analítica i Química Orgànica

Creation date in repository: 2023-05-22

Keywords: -fluoroamination, allyl carbamates, sphingolipid analogs

Title in original language: Metal-Free -Fluoroamination of Allyl Carbamates: Towards the Synthesis of Fluorinated Sphingolipid Analogs

Access Rights: info:eu-repo/semantics/openAccess

Project director: Díaz Giménez, Maria Yolanda