Gluten-degrading enzyme and cocoa extract supplementation as potential strategies to gluten-induced toxicity in a celiac mouse model

Entity: Universitat Rovira i Virgili (URV)

Confidenciality: Si

Education area(s): Nutrició i Metabolisme

APS: No

Title in different languages: Suplementació amb un enzim degradant del gluten i un extracte de cacau com a estratègies potencials davant de la toxicitat induïda pel gluten en un model de murí celíac

Abstract: Gluten-induced gut toxicity it’s a major recurrent effect that may lead to immunological disturbances that can turn out into the development of complex inflammatory pathologies such as irritable bowel syndrome or Inflammatory Bowel Disease among others. Celiac disease (CeD) nowadays is suffered by a great number of people and although a strict gluten-free diet is vital, there is a need to instigate other possible therapeutic strategies to diminish its symptoms. In this study, we investigated the functional, immunological, and morphological gut response in front of the supplementation of a gluten-degrading enzyme and the intake of a cocoa extract in female and male DQ8-Dd-villin-IL-15tg mice that represent the CeD animal model.

Subject: Malaltia celíaca

Academic year: 2023-2024

Language: en

Work's public defense date: 2024-06-20

Subject areas: Biochemistry and biotechnology

Student: López Plana, Marta

Work's codirector: Franch Masferrer, Àngels

Department: Bioquímica i Biotecnologia

Creation date in repository: 2025-05-16

TFM credits: 18

Keywords: Celiac disease, Mouse model, Prevention strategies

Title in original language: Gluten-degrading enzyme and cocoa extract supplementation as potential strategies to gluten-induced toxicity in a celiac mouse model

Access Rights: info:eu-repo/semantics/restrictedAccess

Project director: Pérez Cano, Francisco J.