Gluten-degrading enzyme and cocoa extract supplementation as potential strategies to gluten-induced toxicity in a celiac mouse model

Identifier:  TFM:1959

Handle: https://hdl.handle.net/20.500.11797/TFM1959

Authors:  López Plana, Marta

Abstract:
Gluten-induced gut toxicity it’s a major recurrent effect that may lead to immunological disturbances that can turn out into the development of complex inflammatory pathologies such as irritable bowel syndrome or Inflammatory Bowel Disease among others. Celiac disease (CeD) nowadays is suffered by a great number of people and although a strict gluten-free diet is vital, there is a need to instigate other possible therapeutic strategies to diminish its symptoms. In this study, we investigated the functional, immunological, and morphological gut response in front of the supplementation of a gluten-degrading enzyme and the intake of a cocoa extract in female and male DQ8-Dd-villin-IL-15tg mice that represent the CeD animal model.