Long-term antihypertensive effects and underlying mechanisms of a mixture of protein hydrolysates from a plant-origin coproduct in rats with diet-induced metabolic syndrome

Identifier:  TFM:1961

Handle: https://hdl.handle.net/20.500.11797/TFM1961

Authors:  Serrano López, Alejandro

Abstract:
Agri-food co-products have emerged as a source of bioactive compounds capable of treating hypertension, such as peptide hydrolysates. Therefore, the aim of this study was to obtain a protein hydrolysate with angiotensin-converting enzyme inhibitory (ACEi) activity, which is an enzyme involved in the development of hypertension. Sixty hydrolysates obtained from an agricultural co-product were tested for ACEi activity, selecting hydrolysates H10 and H60 to test their antihypertensive effect in spontaneously hypertensive rats. According to this study, the H60 hydrolysate was found to have antihypertensive activity, making it a promising compound for use as an antihypertensive agent